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Experiência inicial no tratamento endoscópico de fístulas gastrocutâneas pós-gastroplastia vertical redutora através da aplicação de matriz acelular fibrogênica; Endoscopic placement of a "plug" made of acellular biomaterial: a new technique for the repair of gastric leak after Roux-en-Y gastric bypass

MALUF-FILHO, Fauze; LIMA, Marcelo Simas de; HONDO, Fabio; GIORDANO-NAPPI, José Humberto; GARRIDO, Teresa; SAKAI, Paulo
Fonte: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE Colégio Brasileiro de Cirurgia Digestiva - CBCD Sociedade Brasileira de Motilidade Digestiva - SBMD Federação Brasileira de Gastroenterologia - FBGSociedade Brasileira de Hepatologia - SBHSociedade Brasileira de Endoscopia Digestiva - SOBED Publicador: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE Colégio Brasileiro de Cirurgia Digestiva - CBCD Sociedade Brasileira de Motilidade Digestiva - SBMD Federação Brasileira de Gastroenterologia - FBGSociedade Brasileira de Hepatologia - SBHSociedade Brasileira de Endoscopia Digestiva - SOBED
Tipo: Artigo de Revista Científica
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RACIONAL: A gastroplastia redutora à Capella, que combina técnicas restritiva e disabsortiva, é o procedimento bariátrico mais realizado no Brasil. Uma das complicações mais temidas desta operação é a fístula gastrocutânea que ocorre na linha de grampeamento vertical da neocâmara. O tratamento inicial consiste em drenagem adequada, suporte nutricional, bloqueio da produção de ácido e antibioticoterapia. Em 20% a 30% dos casos, a fístula tomará curso crônico. Nestes casos, vários tratamentos endoscópicos têm sido sugeridos. OBJETIVO: Descrever a técnica e os resultados do tratamento endoscópico das fístulas gastrocutâneas decorrentes de operações bariátricas através da aplicação de matriz acelular fibrogênica. MÉTODOS: Nesta série de casos, descrevem-se 25 pacientes com esta complicação tratados de maneira pioneira através da aplicação endoscópica de matriz acelular fibrogênica. O tempo entre o diagnóstico da fístula e a primeira sessão do tratamento endoscópico variou de 4 a 25 semanas, mediana: 7 semanas). RESULTADOS: Dos 25 pacientes, 20 (80%) tiveram a fístula fechada pelo método. Seis deles com uma única sessão (30,0%), 11 necessitaram de duas aplicações (55,0%) e 3 pacientes, de uma terceira sessão (15...

Cardioplasty and Roux-en-Y partial gastrectomy (Serra-Dória procedure) for reoperation of achalasia

Ponciano,Helio; Cecconello,Ivan; Alves,Leosarte; Ferreira,Berivaldo Dias; Gama-Rodrigues,Joaquim
Fonte: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE ; Colégio Brasileiro de Cirurgia Digestiva - CBCD ; Sociedade Brasileira de Motilidade Digestiva - SBMD ; Federação Brasileira de Gastroenterologia - FBG; Sociedade Brasileira de Hepatologia - SBH; Sociedade Brasileira de Endoscopia Digestiva - SOBED Publicador: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE ; Colégio Brasileiro de Cirurgia Digestiva - CBCD ; Sociedade Brasileira de Motilidade Digestiva - SBMD ; Federação Brasileira de Gastroenterologia - FBG; Sociedade Brasileira de Hepatologia - SBH; Sociedade Brasileira de Endoscopia Digestiva - SOBED
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/09/2004 EN
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BACKGROUND: After cardiomyotomy for the treatment of megaesophagus, recurrence of symptoms occur in up to 15% of the patients, but only some require a reoperation. AIM: To evaluate the results of reoperation - cardioplasty with Roux-en-Y partial gastrectomy, a technique proposed by Serra-Dória. CASUISTIC AND METHODS: Twenty patients with achalasia previously treated by cardiomyotomy, were retrospectively studied. The etiology of symptoms recurrence was reflux esophagitis in nine (45.0%) patients, healing of the myotomy in five (25.0%), end staging megaesophagus in five (25.0%) and incomplete myotomy in one (5%). Intra and postoperative complications were analyzed. The patients were studied by clinical (dysphagia, regurgitation, heartburn and weight gain), radiological and endoscopic evaluation, in the pre- and postoperative period. RESULTS: Five (25.0%) patients had complications in the immediate postoperative period. No deaths were observed. Dysphagia improved in all the patients. Regurgitation and heartburn almost disappeared in the whole group. Weight was maintained or increased in 64.7% of the patients. Radiological studies showed a decrease in the caliber of the esophagus in 53.0%, while the remaining patients maintained the pre-operative diameter. Endoscopy...

Endoscopic and ultrasonographic evaluation before and after Roux-en-Y gastric bypass for morbid obesity

Teivelis,Marcelo Passos; Faintuch,Joel; Ishida,Robson; Sakai,Paulo; Bresser,Adriano; Gama-Rodrigues,Joaquim
Fonte: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE ; Colégio Brasileiro de Cirurgia Digestiva - CBCD ; Sociedade Brasileira de Motilidade Digestiva - SBMD ; Federação Brasileira de Gastroenterologia - FBG; Sociedade Brasileira de Hepatologia - SBH; Sociedade Brasileira de Endoscopia Digestiva - SOBED Publicador: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE ; Colégio Brasileiro de Cirurgia Digestiva - CBCD ; Sociedade Brasileira de Motilidade Digestiva - SBMD ; Federação Brasileira de Gastroenterologia - FBG; Sociedade Brasileira de Hepatologia - SBH; Sociedade Brasileira de Endoscopia Digestiva - SOBED
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/03/2007 EN
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BACKGROUND: Esophagogastric abnormalities are recognized prior and after bariatric procedures, but frequency and severity are debated. Liver and biliary tract findings are also of clinical importance, especially gallstones and liver steatosis. AIM: To compare pre-operative findings of hepatobiliary ultrasound and upper digestive endoscopy with post-operative results in patients submitted to open Roux-en-Y gastric bypass for morbid obesity. METHODS: A total of 80 patients were enrolled 16.8 ± 12.1 months after operation, all of them on routine follow-up program, and 8 were excluded. Retrospective analysis aimed at pre-operative clinical, endoscopic and ultrasonographic examinations and were prospectively repeated. RESULTS: Pre-operative endoscopical report was available in 42 cases, and 52 examinations were performed post-operatively. Frequency of esophagitis changed from 16.7% (7/42) to 15.4% (8/52), and of gastritis from 45.2% (19/42) to 21.2% (11/52). Gastric or gastrojejunal ulcers were initially present in 4.8% (2/42) and increased to 9.6% (5/52). Post-operatively, an unusual abnormality was silastic band erosion: 7.7% (4/52). Helicobacter pylori was present in 50.0% (21/42) before and 3.5% (2/52) after operation. Ultrasonographic study had been done before intervention in 63 subjects...

Doença hepática não-alcoólica: evolução após derivação gastrojejunal em Y-de-Roux pela técnica de fobi-capella

Freitas,Alexandre Coutinho Teixeira de; Freitas,Diane Teixeira de; Parolin,Mônica Beatriz; Campos,Antônio Carlos Ligocki; Coelho,Júlio Cezar Uili
Fonte: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE ; Colégio Brasileiro de Cirurgia Digestiva - CBCD ; Sociedade Brasileira de Motilidade Digestiva - SBMD ; Federação Brasileira de Gastroenterologia - FBG; Sociedade Brasileira de Hepatologia - SBH; Sociedade Brasileira de Endoscopia Digestiva - SOBED Publicador: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE ; Colégio Brasileiro de Cirurgia Digestiva - CBCD ; Sociedade Brasileira de Motilidade Digestiva - SBMD ; Federação Brasileira de Gastroenterologia - FBG; Sociedade Brasileira de Hepatologia - SBH; Sociedade Brasileira de Endoscopia Digestiva - SOBED
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/03/2007 PT
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RACIONAL: A doença hepática não-alcoólica apresenta alta prevalência entre pacientes com obesidade mórbida, podendo evoluir de esteatose hepática até esteatohepatite e cirrose. OBJETIVO: Determinar o efeito da derivação gástrica na incidência de doença hepática não-alcoólica e co-morbidades relacionadas em pacientes com obesidade mórbida. MÉTODOS: Os pacientes foram prospectivamente avaliados no pré-operatório e, no mínimo, após 6 meses de pós-operatório. Foram analisados: dados antropométricos, co-morbidades, medicamentos em uso, colesterol, triglicerídeos, provas hepáticas e incidência de doença hepática não-alcoólica. Todos os pacientes com alteração de provas hepáticas foram submetidos a biopsia hepática no peroperatório. RESULTADO: Vinte e oito pacientes com doença hepática não-alcoólica foram incluídos no estudo com índice de massa corpórea médio de 42 ± 4 kg/m². Vinte e cinco pacientes apresentaram 59 co-morbidades, sendo as mais freqüentes: elevação de triglicerídeos (n = 23), elevação de colesterol total (n = 13) e hipertensão arterial (n = 11). Foram submetidos a biopsia 22 pacientes: 10 apresentaram esteatose macrogoticular moderada, 5 esteatose macrogoticular discreta e 7 esteatohepatite. Os doentes foram analisados em média após 230 dias de pós-operatório. Apresentaram perda de 64% do excesso de peso...

An experimental study of the electrical activity of the bypassed stomach in the Roux-en-Y gastric bypass

Ferraz,Álvaro Antônio Bandeira; Leão,Cristiano Souza; Campos,Josemberg Marins; Coelho,Antônio Roberto Barros; Zilbestein,Bruno; Ferraz,Edmundo Machado
Fonte: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE ; Colégio Brasileiro de Cirurgia Digestiva - CBCD ; Sociedade Brasileira de Motilidade Digestiva - SBMD ; Federação Brasileira de Gastroenterologia - FBG; Sociedade Brasileira de Hepatologia - SBH; Sociedade Brasileira de Endoscopia Digestiva - SOBED Publicador: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE ; Colégio Brasileiro de Cirurgia Digestiva - CBCD ; Sociedade Brasileira de Motilidade Digestiva - SBMD ; Federação Brasileira de Gastroenterologia - FBG; Sociedade Brasileira de Hepatologia - SBH; Sociedade Brasileira de Endoscopia Digestiva - SOBED
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/06/2007 EN
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BACKGROUND: Surgical options for morbid obesity are diverse, and the Roux-en-Y gastric bypass, initially described by Fobi has gained popularity. Knowledge about the physiology of the bypassed stomach is limited because this newly produced segment of the stomach is inaccessible to endoscopic or contrast radiological studies. AIM: To evaluate the myoelectric activity of the bypassed stomach and its reply to the feeding. METHODS: An experimental protocol was conducted to evaluate postoperative gastric bypassed motility in dogs submitted to the Roux-en-Y gastric bypass procedure. Two groups of five animals were studied on postoperative fasting and after a standard meal, recording electrical response and control activity. Both control and Roux-en-Y gastric bypass operated study group had a pair of electrodes placed on three points of the remaining stomach: fundus, body and antrum. Data registration was performed after complete ileus resolution, and analysed with DATA Q Inst. series 200. RESULTS: The results achieved on the conditions of this study suggest that: 1. the remaining stomach maintain the same pattern of motility; 2. there is a reduced fasting electromyography activity following the Roux-en-Y gastric bypass procedure; 3. significantly reduced fasting electric control activity when compared both groups...

Radiographic study of patients submitted to total gastrectomy using Safatle reconstruction technique

Meyer,Alberto Luiz Monteiro; Berger,Eduardo; Monteiro Jr.,Orlando; Alonso,Paulino Alberto; Lerner,João Sadi
Fonte: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE ; Colégio Brasileiro de Cirurgia Digestiva - CBCD ; Sociedade Brasileira de Motilidade Digestiva - SBMD ; Federação Brasileira de Gastroenterologia - FBG; Sociedade Brasileira de Hepatologia - SBH; Sociedade Brasileira de Endoscopia Digestiva - SOBED Publicador: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE ; Colégio Brasileiro de Cirurgia Digestiva - CBCD ; Sociedade Brasileira de Motilidade Digestiva - SBMD ; Federação Brasileira de Gastroenterologia - FBG; Sociedade Brasileira de Hepatologia - SBH; Sociedade Brasileira de Endoscopia Digestiva - SOBED
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/09/2008 EN
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BACKGROUND: Ever since the first total gastrectomy, there has always been a great concern in increasing the survival of patients, and with the advance of techniques, in improving the quality of life of these patients. The most common reconstruction technique of the gastrointestinal transit is the Roux-en-Y. The reposition of a functional pouch in place of the resected stomach was proposed to minimize the postprandial symptoms, improve the nutritional grade and consequently, the quality of life. The Safatle reconstruction of the gastrointestinal transit technique consists of, in short, in the association of the interposition of the jejunal loop with partial transit through the duodenum, with an inverted Roux-en-Y and with the creation of a pouch which resembles the dynamics of the stomach, achieved by duodenojejunal segment which has an antiperistalsis emptying. AIM: To assess, by radiographic means, the emptying of the duodenojejunal pouch in patients submitted to total gastrectomy using the Safatle reconstruction technique. METHOD: Twelve patients submitted to total gastrectomy using the Safatle technique due to gastric cancer were studied. They were summoned to perform contrasted radiographies of the esophagus-duodenum-jejunum by the videofluoroscopic method during the months of July and August...

Early marginal ulcer following Roux-en-Y gastric bypass under proton pump inhibitor treatment: prospective multicentric study

Garrido Jr.,Arthur Belarmino; Rossi,Marçal; Lima Jr.,Sizenando Ernesto; Brenner,Antonio Sérgio; Gomes Jr,Claudio Antonio Rufino
Fonte: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE ; Colégio Brasileiro de Cirurgia Digestiva - CBCD ; Sociedade Brasileira de Motilidade Digestiva - SBMD ; Federação Brasileira de Gastroenterologia - FBG; Sociedade Brasileira de Hepatologia - SBH; Sociedade Brasileira de Endoscopia Digestiva - SOBED Publicador: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE ; Colégio Brasileiro de Cirurgia Digestiva - CBCD ; Sociedade Brasileira de Motilidade Digestiva - SBMD ; Federação Brasileira de Gastroenterologia - FBG; Sociedade Brasileira de Hepatologia - SBH; Sociedade Brasileira de Endoscopia Digestiva - SOBED
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/06/2010 EN
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CONTEXT: Causal factors of gastrojejunal ulcers after Roux-en-Y gastric bypass include peptic acid secretion from the gastric pouch. Esomeprazole is a potent inhibitor of acid secretion. OBJECTIVE: To assess the occurrence of dyspepsia and gastrojejunal ulcers within the first 2 months after Roux-en-Y gastric bypass during the use of esomeprazole. METHODS: One hundred eighteen morbid obese subjects were submitted to Roux-en-Y gastric bypass. Preoperative upper gastrointestinal tract endoscopy was negative for H. pylori. All subjects received esomeprazole for 60 days after surgery. RESULTS: Two weeks after surgery only 13 mild symptoms were reported. After 2 months, 17 also moderate complaints were registered. Endoscopy around the 60th day showed esophagitis in 10 (8.5%), hiatal hernia in 2 (1.7%), foreign body in the anastomotic line in 12 (10.2%) and gastrojejunal ulcers was observed in 9 (7.6%) subjects, 2 of which had a suture material or metallic staple granuloma in the gastrojejunostomy. Ten subjects took nonsteroidal anti-inflammatory drugs at least once during study, but none of them developed ulcer. None of the subjects with ulcer had dyspeptic symptoms. CONCLUSION: The incidence of ulcer in the gastrojejunal anastomosis within the first 2 months following Rouxen-Y gastric bypass under proton pump inhibitors is considerable. It was not related to the use of non-steroidal anti-inflammatory drugs...

CONTROL OF HYPERTENSION AFTER ROUX-EN-Y GASTRIC BYPASS AMONG OBESE DIABETIC PATIENTS

CAZZO,Everton; GESTIC,Martinho Antonio; UTRINI,Murillo Pimentel; MACHADO,Ricardo Rossetto; PAREJA,José Carlos; CHAIM,Elinton Adami
Fonte: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE ; Colégio Brasileiro de Cirurgia Digestiva - CBCD ; Sociedade Brasileira de Motilidade Digestiva - SBMD ; Federação Brasileira de Gastroenterologia - FBG; Sociedade Brasileira de Hepatologia - SBH; Sociedade Brasileira de Endoscopia Digestiva - SOBED Publicador: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE ; Colégio Brasileiro de Cirurgia Digestiva - CBCD ; Sociedade Brasileira de Motilidade Digestiva - SBMD ; Federação Brasileira de Gastroenterologia - FBG; Sociedade Brasileira de Hepatologia - SBH; Sociedade Brasileira de Endoscopia Digestiva - SOBED
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/03/2014 EN
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Context Hypertension is a common disorder in general practice and has a widely known association with type 2 diabetes mellitus. Low adhesion to clinical treatment may lead to poor results. Obesity surgery can bring early and relevant resolution rates of both morbidities. Objective To describe hypertension evolution after Roux-en-Y gastric bypass in patients with type 2 diabetes mellitus. Method Descriptive observational study designed as a historical cohort of 90 subjects with hypertension and diabetes who underwent Roux-en-Y gastric bypass and were evaluated before and after surgery. Results It was observed a hypertension resolution rate of 85.6% along with markedly decrease in anti-hypertensive usage. Mean resolution time was 3.2 months. Resolution was associated with homeostasis model assessment – insulin resistance, preoperative fasting insulin, anti-hypertensive usage, hypertension time, body mass index and percentage of weight loss. Resolution of hypertension was not statistically associated with diabetes remission within this sample. Conclusion Roux-en-Y gastric bypass was a safe and effective therapeutic tool to achieve hypertension resolution in patients who also had diabetes mellitus.

OUTCOMES ON QUALITY OF LIFE, WEIGHT LOSS, AND COMORBIDITIES AFTER ROUX-EN-Y GASTRIC BYPASS

COSTA,Roberto Coelho Netto da Cunha; YAMAGUCHI,Nagamassa; SANTO,Marco Aurelio; RICCIOPPO,Daniel; PINTO-JUNIOR,Paulo Engler
Fonte: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE ; Colégio Brasileiro de Cirurgia Digestiva - CBCD ; Sociedade Brasileira de Motilidade Digestiva - SBMD ; Federação Brasileira de Gastroenterologia - FBG; Sociedade Brasileira de Hepatologia - SBH; Sociedade Brasileira de Endoscopia Digestiva - SOBED Publicador: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE ; Colégio Brasileiro de Cirurgia Digestiva - CBCD ; Sociedade Brasileira de Motilidade Digestiva - SBMD ; Federação Brasileira de Gastroenterologia - FBG; Sociedade Brasileira de Hepatologia - SBH; Sociedade Brasileira de Endoscopia Digestiva - SOBED
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/09/2014 EN
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Context Bariatric surgery has become the most effective method for producing weight loss in obese patients. The evaluation of improvement of comorbidities and changes in the quality of life are important outcome factors; however, it is necessary to investigate whether they persist over the long term. Methods A cross-sectional study was conducted on 143 obese patients from our institution from February 2007 to February 2008. These patients were divided into five independent groups, one being a control group, plus four other groups with 1, 2, 3, 4 or more years following surgical Roux-en-Y gastric bypass with a silicon ring banded. quality of life forms and anthropometric measurements were performed and its scores correlated with social factors, weight loss success, and status of obesity-related conditions. Results For the group that was 1 year postoperative, a significant percentage of excess body weight loss (EBWL%) of 81.7% was observed. The groups with 2, 3, 4 or more years of post-surgical follow-up showed a EBWL decline, but without significant difference. The main comorbidity percentages in all patients who had the surgery was as follows: 69.7% for hypertension; 88.2% for diabetes mellitus; and 27.5% for arthropathy. There was a significant decrease in the rate for diabetes resolution (P = 0.035) observed by evolutionary assessment of the comorbidity resolution. The results obtained by BAROS were good...

AGE AND GENDER MAY INFLUENCE THE RESULTS OF ROUX-EN-Y GASTRIC BYPASS? Metabolic syndrome parameters

ANDRADE-SILVA,Stephan Garcia; CARANTI,Danielle Arisa; SALLET,José Afonso; LEAL,Lucas Pedroso Fernandes Ferreira; LEAL,Antonio Joaquim Ferreira; DÂMASO,Ana Raimunda
Fonte: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE ; Colégio Brasileiro de Cirurgia Digestiva - CBCD ; Sociedade Brasileira de Motilidade Digestiva - SBMD ; Federação Brasileira de Gastroenterologia - FBG; Sociedade Brasileira de Hepatologia - SBH; Sociedade Brasileira de Endoscopia Digestiva - SOBED Publicador: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE ; Colégio Brasileiro de Cirurgia Digestiva - CBCD ; Sociedade Brasileira de Motilidade Digestiva - SBMD ; Federação Brasileira de Gastroenterologia - FBG; Sociedade Brasileira de Hepatologia - SBH; Sociedade Brasileira de Endoscopia Digestiva - SOBED
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/09/2014 EN
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Context Severe obesity affects the body favoring the development of serious diseases, including hypertension, diabetes mellitus, atherosclerosis and non alcoholic fatty liver disease. Bariatric procedures increased in Brazil in the last decade. Objectives The purpose of this study was to verify if gender and age in date of procedure resulted significant differences in metabolic syndrome parameters after surgery. Methods The study involved 205 medical records of adult patients undergoing Roux-en-Y gastric bypass, stratified by gender and age groups and followed one year by a multidisciplinary team. Results It was observed significant decrease in body mass index, fasting glucose and insulin at all ages and both genders. Lipid profile showed significant improvements except high density lipoprotein cholesterol. Ectopic fat in the liver has decreased after 6 months in patients classified with steatosis at baseline. Patients classified as hypertensive blood pressure levels decreased 6 months after surgical intervention. Conclusions Roux-en-Y gastric bypass proved to be an important tool in remission of metabolic syndrome parameters. The reduction of body mass accompanied to decrease in insulin resistance resulted in lower prevalence of comorbidities associated with obesity. The benefits were similar and extended both genders and all age groups between 18 and 65 years old.

IMPACT ON QUALITY OF LIFE, WEIGHT LOSS AND COMORBIDITIES: a study comparing the biliopancreatic diversion with duodenal switch and the banded Roux-en-Y gastric bypass

DUARTE,Maria Ignez Xavier de Toledo; BASSITT,Debora Pastore; AZEVEDO,Otávio Cansanção de; WAISBERG,Jaques; YAMAGUCHI,Nagamassa; PINTO JUNIOR,Paulo Engler
Fonte: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE ; Colégio Brasileiro de Cirurgia Digestiva - CBCD ; Sociedade Brasileira de Motilidade Digestiva - SBMD ; Federação Brasileira de Gastroenterologia - FBG; Sociedade Brasileira de Hepatologia - SBH; Sociedade Brasileira de Endoscopia Digestiva - SOBED Publicador: Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE ; Colégio Brasileiro de Cirurgia Digestiva - CBCD ; Sociedade Brasileira de Motilidade Digestiva - SBMD ; Federação Brasileira de Gastroenterologia - FBG; Sociedade Brasileira de Hepatologia - SBH; Sociedade Brasileira de Endoscopia Digestiva - SOBED
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/12/2014 EN
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Context Few studies have evaluated the results of different types of bariatric surgery using the Medical Outcome Study 36 - Health Survey Short-Form (SF-36) quality of life questionnaire, the Bariatric and Reporting Outcome System (BAROS) and the reviewed Moorehead-Ardelt Quality of Life II Questionnaire (M-A QoLQ II) that is part of BAROS. The Roux-en-Y gastric bypass (RYGB) is the most common morbid obesity surgery worldwide. However, there is evidence indicating that a biliopancreatic diversion with duodenal switch (DS) is more effective than RYGB in weight loss terms. Objectives To evaluate the impact of different types of bariatric surgery on quality of life, comorbidities and weight loss. Methods Two groups of patients who underwent bariatric surgery conventional Banded Roux-en-Y gastric bypass (BRYGB) or DS were evaluated through monitoring at 12 to 36 months after surgery, as well as a control group of obese patients who had not undergone surgery. The tools used for this were SF-36, BAROS and M-A QoLQ II. The DS group consisted of 17 patients and the BRYGB group consisted of 20. The control group comprised 20 independent, morbidly obese individuals. Results The mean age of the patients in the groups was 45.18 in the DS group...

Effect of lactose hydrolysis during manufacture and storage of drinkable yogurt

Vénica, Claudia Inés; Bergamini, Carina Viviana; Zalazar, Carlos Antonio; Perotti, Maria Cristina
Fonte: SciTechnol Publicador: SciTechnol
Tipo: info:eu-repo/semantics/article; info:ar-repo/semantics/artículo; info:eu-repo/semantics/publishedVersion Formato: application/pdf
ENG
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Reduced-lactose yogurts are still not available in the Argentinean market despite the fact in Latin America the incidence of deficientlactose individual is very high. In this work, variables to hydrolyze the lactose (three levels of β-galactosidase enzyme and the time of its addition) were evaluated during manufacture of natural and sweetened (8% p/v) drinkable yogurts. Experimental yogurts (with enzyme) were compared with controls (without enzyme). The evolution of lactose content, pH, titratable acidity and syneresis were analyzed during 28 days of storage at 5ºC. Results showed feasibility in the simultaneous addition of enzyme and starter. The hydrolysis percentages in experimental yogurts ranged from 74 to 93% at the end of manufacture and stayed without changes during storage. For control yogurts, the lactose content decreased approximately 15%, which was doubled at 14 days. The inclusion of sucrose did not substantially affect the hydrolysis process. After 14 days, the pH and acidity in experimental yogurts were slightly higher and lower, respectively, in comparison to controls. On the other hand, the sensory panel found that the reduced-lactose and traditional yogurt where similar.; Fil: Vénica, Claudia Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico - CONICET - Santa Fe. Instituto de Lactologia Industrial; Argentina;; Fil: Bergamini...

Divergent mechanisms of interaction of Helicobacter pylori and Campylobacter jejuni with mucus and mucins

Naughton, Julie; Mariño, Karina Valeria; Dolan, Brendan; Reid, Colm; Gough, Ronan; Gallagher, Mary E.; Kilcoyne, Michelle; Gerlach, Jareth Q.; Joshi, Lokesh; Rudd, Pauline M; Carrington, Stephen; Bourke, Billy; Clyne, Marguerite
Fonte: American Society For Microbiology Publicador: American Society For Microbiology
Tipo: info:eu-repo/semantics/article; info:ar-repo/semantics/artículo; info:eu-repo/semantics/publishedVersion Formato: application/pdf
ENG
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Helicobacter pylori and Campylobacter jejuni colonize the stomach and intestinal mucus, respectively. Using a combination of mucus-secreting cells, purified mucins, and a novel mucin microarray platform, we examined the interactions of these two organisms with mucus and mucins. H. pylori and C. jejuni bound to distinctly different mucins. C. jejuni displayed a striking tropism for chicken gastrointestinal mucins compared to mucins from other animals and preferentially bound mucins from specific avian intestinal sites (in order of descending preference: the large intestine, proximal small intestine, and cecum). H. pylori bound to a number of animal mucins, including porcine stomach mucin, but with less avidity than that of C. jejuni for chicken mucin. The strengths of interaction of various wild-type strains of H. pylori with different animal mucins were comparable, even though they did not all express the same adhesins. The production of mucus by HT29-MTX-E12 cells promoted higher levels of infection by C. jejuni and H. pylori than those for the non-mucus-producing parental cell lines. Both C. jejuni and H. pylori bound to HT29-MTX-E12 mucus, and while both organisms bound to glycosylated epitopes in the glycolipid fraction of the mucus...

A model to predict the response to therapy against hepatitis C virus (HCV) including low-density lipoprotein receptor genotype in HIV/HCV-coinfected patients

Neukam, Karin; Almeida, Carmen; Caruz, Antonio; Rivero Juarez, Antonio; Rallon, Norma; Di Lello, Federico Alejandro; Herrero, Rocío; Camacho, Angela; Benito, José; Macias, Juan; Rivero, Antonio; Soriano, Vicente; Pineda, Juan Antonio
Fonte: Oxford University Press Publicador: Oxford University Press
Tipo: info:eu-repo/semantics/article; info:ar-repo/semantics/artículo; info:eu-repo/semantics/publishedVersion Formato: application/pdf
ENG
Relevância na Pesquisa
500.73258%
Accurate prediction of sustained virological response (SVR) to pegylated interferon-a (Peg-IFN) plus ribavirin in HIV/hepatitis C virus (HCV)-coinfected patients could improve the management of these patients. We aimed to develop a model to predict SVR to Peg-IFN/ribavirin in HIV/HCV-coinfected individuals combining HCV genotype and baseline HCV RNA load with interleukin 28B and low-density lipoprotein receptor genetic variations.; Fil: Neukam, Karin. Hospital Universitario de Valme. Unidad de Enfermedades Infecciosas y Microbiología; España;; Fil: Almeida, Carmen. Hospital Universitario de Valme. Unidad de Investigación; España;; Fil: Caruz, Antonio. Universidad de Jaén; España;; Fil: Rivero Juarez, Antonio. Hospital Universitario Reina Sofía. Instituto Maimónides de Investigación Biomédica de Córdoba. Unidad de Enfermedades Infecciosas; España;; Fil: Rallon, Norma. Hospital Carlos III. Departamento de Enfermedades Infecciosas; España;; Fil: Di Lello, Federico Alejandro. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Virología; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina; Hospital Universitario de Valme. Unidad de Enfermedades Infecciosas y Microbiología; España;; Fil: Herrero...

Variations at multiple genes improve interleukin 28B genotype predictive capacity for response to therapy against hepatitis C infection

Neukam, Karin; Caruz, Antonio; Rivero Juarez, Antonio; Barreiro, Pablo; Merino, Dolores; Real, Luis M.; Herrero, Rocío; Camacho, Angela; Soriano, Vicente; Di Lello, Federico Alejandro; Macias, Juan; Rivero, Antonio; Pineda, Juan A.
Fonte: Lippincott, Williams & Wilkins Publicador: Lippincott, Williams & Wilkins
Tipo: info:eu-repo/semantics/article; info:ar-repo/semantics/artículo; info:eu-repo/semantics/publishedVersion Formato: application/pdf
ENG
Relevância na Pesquisa
501.1351%
To identify genetic factors that predict sustained virological response (SVR) to pegylated interferon (Peg-IFN)/ribavirin (RBV) in HIV/hepatitis C virus (HCV) genotype 1 or 4-coinfected patients and that enhance the predictive capacity of IL28B genotype in this population.; Fil: Neukam, Karin. Hospital Universitario de Valme. Unidad de Enfermedades Infecciosas y Microbiología; España; Instituto de Biomedicina de Sevilla; España;; Fil: Caruz, Antonio. Universidad de Jaén; España;; Fil: Rivero Juarez, Antonio. Instituto Maimónides de Investigación Biomédica de Córdoba. Hospital Universitario Reina Sofía. Unidad de Enfermedades Infecciosas; España;; Fil: Barreiro, Pablo. Hospital Carlos III. Departamento de Enfermedades Infecciosas; España;; Fil: Merino, Dolores. Hospital Juan Ramón Jiménez. Unidad de Enfermedades Infecciosas; España;; Fil: Real, Luis M.. Hospital Universitario de Valme. Unidad de Enfermedades Infecciosas y Microbiología; España; Instituto de Biomedicina de Sevilla; España;; Fil: Herrero, Rocío. Universidad de Jaén; España;; Fil: Camacho, Angela. Instituto Maimónides de Investigación Biomédica de Córdoba. Hospital Universitario Reina Sofía. Unidad de Enfermedades Infecciosas; España;; Fil: Soriano...

Helicobacter pylori heterogeneity in patients with gastritis and peptic ulcer disease

Armitano, Rita Ines; Matteo, Mario José; Goldman, Cinthia Gabriela; Wonaga, Andrés; Viola, Luis Alberto; Zerbetto de Palma, Gerardo Gabriel; Catalano, Mariana
Fonte: Elsevier Publicador: Elsevier
Tipo: info:eu-repo/semantics/article; info:ar-repo/semantics/artículo; info:eu-repo/semantics/publishedVersion Formato: application/pdf
ENG
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527.60523%
Genetic diversification allows Helicobacter pylori to persist during chronic colonization/infection. We investigated the intra-host variation of several markers that suggested microevolution in patients with chonic gastritis (CG) and peptic ulcer disease (PUD). One-hundred twenty-six isolates recovered from 14 patients with CG and 13 patients with PUD were analysed. cag pathogenicity island (cagPAI), oipA, vacA, bab gene status and the presence of jhp0926, jhp0945, jhp0947, jhp0949 and jhp0940 genes from the genomic Plasticity Zone (PZ) were taken into accout to investigate intra-host variation. lspA-glmMRFLP was performed to identify mixed infections. Only one patient was colonised/infected by two ancestrally unrelated strains. Among the 126 isolates, a significant association among cagPAI genotypes, oipA status and vacA alleles was indicated. Complete cagPAI, oipA ??on??, and vacA s1-m1 variants were significantly found in patients with PUD, without intra-host variations. Isolates from 7/14 patients with CG lacked babA in all chromosomal loci. In contrast, isolates from all or several biopsies of PUD patients carried babA, but in one patient only, the isolates showed positive Lewis b (Leb) binding assay. Considering cagPAI, vacA...

Inhibition of Water Absorption and Selective Damage to Human Colonic Mucosa Are Induced by Subtilase Cytotoxin Produced by Escherichia coli O113:H21

Gerhardt, Elizabeth; Masso, Mariana Guillermina; Paton, Adrienne W.; Paton, James C.; Zotta, Elsa; Ibarra, Cristina Adriana
Fonte: American Society for Microbiology Publicador: American Society for Microbiology
Tipo: info:eu-repo/semantics/article; info:ar-repo/semantics/artículo; info:eu-repo/semantics/publishedVersion Formato: application/pdf
ENG
Relevância na Pesquisa
499.76055%
Shiga toxin-producing Escherichia coli O157:H7 (STEC) is by far the most prevalent serotype associated with hemolytic uremic syndrome (HUS) although many non-O157 STEC strains have been also isolated from patients with HUS. The main virulence factor of STEC is the Shiga toxin type 2 (Stx2) present in O157 and non-O157 strains. Recently, another toxin, named subtilase cytotoxin (SubAB), has been isolated from several non-O157 strains and may contribute to the pathogenesis of HUS. Here, we have demonstrated that an O113:H21 STEC strain expressing SubAB and Stx2 inhibits normal water absorption across human colon and causes damage to the surface epithelium, necrosis, mononuclear inflammatory infiltration, edema, and marked mucin depletion. This damage was less marked, but nevertheless significant, when purified SubAB or E. coli O113:H21 expressing only SubAB was assayed. This is the first study showing that SubAB may directly participate in the mechanisms of diarrhea in children infected with non-O157 STEC strains.; Fil: Gerhardt, Elizabeth. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas. Laboratorio de Fisiopatogenia; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina;; Fil: Masso...

The importance of analytical methodology in accurate diagnosis and monitoring of intrahepatic cholestasis of pregnancy

Martinefski, Manuela Romina; Contin, Mario Daniel; Samassa, Paula; Di Carlo, Maria Beatriz; Lucangioli, Silvia Edith; Tripodi, Valeria Paula
Fonte: Elsevier Publicador: Elsevier
Tipo: info:eu-repo/semantics/article; info:ar-repo/semantics/artículo; info:eu-repo/semantics/publishedVersion Formato: application/pdf
ENG
Relevância na Pesquisa
501.7544%
The present case demonstrates the problematic results associated with routine liver tests and enzymatically determined serum total bile acids (TBA).The optimal way to diagnose intrahepatic cholestasis of pregnancy accurately and follow its progression is through evaluation of bile acid profile and serum TBA. In the present case, the determination of these parameters via capillary electrophoresis optimized management. Regular monitoring of this disease with adequate analytical methodology is important.; Fil: Martinefski, Manuela Romina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química Analítica; Argentina;; Fil: Contin, Mario Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química Analítica; Argentina;; Fil: Samassa, Paula. Universidad de Buenos Aires. Facultad de Farmacia y Bioquimica. Departamento de Quimica Analitica y Fisicoquimica. Cat.de Quimica Analitica;; Fil: Di Carlo, Maria Beatriz. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina;; Fil: Lucangioli, Silvia Edith. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica; Argentina; Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina; Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina;; Fil: Tripodi...

Análisis de los premios a la investigación en gastroenterología: Experiencia en México

Chávez-Tapia,Norberto C.; Téllez-Avila,Félix I.; Hernández-Caballeros,Jorge; López-Arce,Gustavo; Franco-Guzmán,Ada; Uribe,Misael
Fonte: Medicina (Buenos Aires) Publicador: Medicina (Buenos Aires)
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/04/2008 ES
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520.5607%
El impacto internacional de la investigación gastroenterológica mexicana es limitado. Se desconoce cuál ha sido el resultado final de los trabajos de mejor calidad a nivel nacional de acuerdo a la Asociación Mexicana de Gastroenterología (AMG). El objetivo de este trabajo fue analizar el patrón de publicación e impacto en las publicaciones periódicas internacionales de los trabajos premiados por la AMG. Se revisaron las memorias del congreso anual de la AMG, período 1998-2006. Se seleccionaron resúmenes donde se indicara premiación o presentación en sesión plenaria. Los trabajos identificados fueron buscados en bases de datos electrónicas, o bien se contactó alguno de los autores para solicitar la información relacionada. De aquellos trabajos publicados en revistas con factor de impacto se buscaron las citas relacionadas. Se localizaron 35 premios, 57.1% fueron en el área de gastroenterología y 34.3% en hepatología. Las instituciones con los premios son Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (48.6%), Instituciones de Educación Superior (31.4%), Instituto Mexicano del Seguro Social (8.6%), Fundación Clínica Médica Sur (5.7%), Hospital Juárez (2.9%), Hospital privado (2.9%). De estos se han publicado 19 (54.8%)...

Enteroscopia de doble balón reporte preliminar servicio de gastroenterología hospital universitario de Maracaibo-Venezuela

Añez,Marianela; Romero,Gisela; Rangel,Rosa; Lizarzábal,Maribel
Fonte: Sociedad Venezolana de Gastroentereología Publicador: Sociedad Venezolana de Gastroentereología
Tipo: Artigo de Revista Científica Formato: text/html
Publicado em 01/03/2008 ES
Relevância na Pesquisa
422.00336%
La experiencia de enteroscopia doble balón como abordaje del intestino delgado en su totalidad, data del año 2001 y pocos han sido los reportes en Venezuela. Nos propusimos presentar la experiencia con este novedoso método, del Servicio de Gastroenterología del Hospital Universitario de Maracaibo „Centro Regional de Referencia de Gastroenterología, Endoscopia y Hepatología‰. Métodos: se realizaron 32 procedimientos de enteroscopia doble balón en 27 pacientes, 24 por abordaje anterógrado, 8 abordaje retrógrado y 4 por abordaje combinado. Se revisaron las indicaciones, los hallazgos, la realización de procedimientos terapéuticos y las complicaciones. Resultados: la inserción del enteroscopio más allá del ligamento de Treitz fue de 100% y de la válvula ileocecal (62,5%). La observación de la totalidad del intestino delgado fue posible en 4 (12,5%) de los pacientes con acceso combinado. Se encontraron hallazgos positivos en 20 (62,5%) de 32 procedimientos. Se realizó terapia endoscópica en 9 con sangrado de origen oscuro con presencia de malformaciones. Se tomaron 8 biopsias. No hubo complicaciones. Conclusiones: la enteroscopia doble balón es un procedimiento efectivo y seguro que permite la evaluación completa del intestino delgado con la posibilidad de tomar biopsias para diagnóstico y realizar terapia endoscópica...